Oxygenated hemoglobin mass fraction in red blood cells (HbO₂ mass fraction)
This test measures the proportion of oxygen-bound hemoglobin in your red blood cells, which reflects how effectively your blood carries oxygen to tissues.
["Helps assess oxygen delivery efficiency in your body, often used in conjunction with other blood oxygen measures."]
Key facts at a glance
- LOINC
- 2716-9
- Short code
- OxyHgb MFr BldV
- Synonyms
- OxyHgb MFr BldV
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
This test measures the levels of specific substances in your body, such as proteins, hormones, or other important markers, to help your healthcare provider evaluate how well certain organs and systems are functioning and to detect possible health conditions early.
Your blood contains hemoglobin, the protein that carries oxygen from your lungs to other parts of your body. This test specifically looks at the fraction of hemoglobin molecules that are saturated with oxygen (HbO₂). While not a standalone diagnostic test, it can be part of broader evaluations for conditions affecting oxygen transport, such as anemia or respiratory disorders.
Your doctor may order this test if you are experiencing unexplained symptoms, if you have a medical condition that requires ongoing monitoring, or as part of a routine checkup to screen for potential health problems before they cause noticeable issues.
Doctors may order this test if you have symptoms like fatigue, shortness of breath, or other signs of poor oxygen utilization. It may also be part of a comprehensive blood workup for conditions like chronic obstructive pulmonary disease (COPD), heart failure, or certain types of anemia.
A small blood sample is usually drawn from a vein in your arm by a trained professional. Depending on the type of test, you may need to fast for several hours beforehand or avoid certain medications, so always follow the specific instructions your provider gives you.
A small blood sample is drawn from a vein, typically in your arm. The blood is processed to separate red blood cells, and the test measures the oxygen-bound hemoglobin content. This is usually done in a laboratory using specialized equipment to analyze the hemoglobin fraction accurately.
Before the test, your healthcare provider will review your medical history, explain the purpose of the test, and give you instructions about eating, drinking, or taking medications. The procedure itself is quick, and you can typically return to your normal activities right afterward.
No special preparation is usually needed, but you may be asked to fast for 8–12 hours if your blood test includes other components. Avoid smoking or caffeine for a few hours before the test if instructed by your healthcare provider.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
HbO₂ mass fraction
Frequently asked questions
This test is often integrated into broader evaluations of oxygen transport and can complement other measures like oxygen saturation (SpO₂) or arterial blood gases. While less commonly standalone, it may help identify subtle imbalances in oxygen delivery, especially in patients with complex conditions like chronic lung disease or heart failure.
A low HbO₂ mass fraction might suggest inefficient oxygen utilization, which could be due to anemia, poor circulation, or other metabolic issues. A high fraction could indicate over-saturation of hemoglobin with oxygen, though this is less common and may warrant further investigation.
No, this test requires a laboratory setting and a blood sample. Home-based oxygen saturation monitors (SpO₂) measure a different aspect of oxygen levels and are not the same as HbO₂ mass fraction.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy