Skip to content

Serum/plasma probe for *Escherichia coli* antigen (qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of *Escherichia coli* bacteria in your blood or plasma, often used to detect infections caused by this common gut bacterium that can sometimes spread to other parts of the body.

Quick summary

["A simple blood test to identify possible *E. coli* infections outside the digestive tract."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97631-6
Short code
P aerugns DNA Snv Ql NAA+n-prb
Synonyms
P aerugns DNA Snv Ql NAA+n-prb
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fever, chills, or unusual fatigue combined with a recent infection (e.g., urinary tract, gastrointestinal, or wound). It helps determine if *E. coli* is the cause of a systemic (body-wide) infection beyond the usual site.

How the Test Works

The test detects specific proteins (antigens) produced by *E. coli* bacteria in your blood or plasma. If present, it confirms infection by this bacterium, though not all *E. coli* strains cause infections outside the gut.

Common Symptoms to Watch For

Symptoms like sepsis (severe infection spreading to blood), kidney issues, or unexplained fever may prompt this test. It’s not a routine screening test but is used in specific clinical scenarios.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, similar to other routine blood tests. Results are qualitative (yes/no) rather than quantitative.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate *E. coli* infection in the bloodstream, which requires urgent medical attention. Negative results mean no detectable *E. coli* antigens were found, but other causes of symptoms must still be evaluated. This test is critical for guiding appropriate antibiotics or treatments.

Short name

E. coli Antigen Test (Qualitative)

Frequently asked questions

What does a positive result mean?
A positive result suggests *E. coli* is causing an infection in your blood or plasma. This requires immediate medical evaluation to determine the best treatment, which may include antibiotics or supportive care.
Can this test detect all types of *E. coli* infections?
No, this test only detects *E. coli* antigens in blood/plasma. Not all *E. coli* strains infect outside the gut, and some infections may not produce detectable antigens. Other tests or cultures may be needed for full diagnosis.
Will I need follow-up tests if this test is positive?
Yes, a positive result will prompt further testing (e.g., blood cultures, imaging) to pinpoint the infection’s source and guide treatment. Your provider will work with you to develop a plan based on the full clinical picture.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy