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Protein Electrophoresis on Serum/Plasma (Qualitative or Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different proteins in your blood, which helps identify abnormalities in protein levels that may indicate conditions like kidney disease, liver problems, or certain cancers.

Quick summary

["Protein electrophoresis helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76593-3
Short code
P aerug regA XXX.tiss NAA+probe
Synonyms
P aerug regA XXX.tiss NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Measured?

Electrophoresis separates blood proteins based on size and electrical charge, revealing distinct bands corresponding to albumin, globulins (including alpha, beta, and gamma fractions), and other proteins. This pattern can highlight imbalances.

Why Is This Test Done?

Your doctor may order this test to check for conditions like multiple myeloma (cancer of plasma cells), liver disease, kidney disease, or autoimmune disorders, where protein levels or patterns differ from normal.

Sample Collection and Preparation

A blood sample is drawn, and serum or plasma is separated for testing. Some labs may use a 24-hour urine collection for specific protein fractions (e.g., albuminuria). Results are qualitative (yes/no) or quantitative (measured amounts).

How Results Are Interpreted

Abnormal patterns—such as a spike in a particular protein band or reduced albumin—may signal underlying health issues. Your doctor will compare results to your symptoms and other tests for diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein Electrophoresis

Frequently asked questions

Can I eat or drink before this test?
For standard serum/plasma electrophoresis, fasting is usually not required, but follow your doctor’s instructions. For urine-based protein electrophoresis (e.g., 24-hour urine), avoid high-protein foods for 24 hours before collection.
How long will it take to get results?
Results are typically available within 24–48 hours, depending on lab processing. Follow-up may be needed if further testing is required.
What if my results are abnormal?
If your results show unusual protein patterns, your doctor may recommend additional tests (e.g., liver/kidney function tests) or further evaluation to determine the cause, such as genetic testing or biopsies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy