Plasma Chromogenic Substrate Activity for Protease Inhibitor 1 (e.g., Alpha-1 Antitrypsin)

What Does This Test Measure?

Alpha-1 Antitrypsin is a protein produced mainly in the liver. It acts as an inhibitor to prevent enzymes from breaking down healthy tissues, particularly in the lungs and liver. This test evaluates its functional activity in your blood plasma, which can help assess whether your body is producing enough of this protein to protect against damage.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have a family history of Alpha-1 Antitrypsin deficiency, symptoms of lung diseases (like emphysema or chronic bronchitis), or liver problems. It can also be used to monitor treatment effectiveness or screen for genetic conditions.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then processed to separate plasma, where the protease activity of Alpha-1 Antitrypsin is measured using a specialized biochemical method that detects its ability to inhibit protease enzymes.

What Are Possible Results?

Results are reported as a functional activity level, which helps determine if your Alpha-1 Antitrypsin is functioning normally. Abnormal results may indicate insufficient production or dysfunction of this protein.