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Plasma/Serum Alpha-1 Antitrypsin (A1AT) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and can be important if you have a family history of lung or liver conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17467-2
Short code
PAI2 Ag PPP IA-aCnc
Synonyms
PAI2 Ag PPP IA-aCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of lung diseases like emphysema or chronic bronchitis, liver problems, or if you have a family history of Alpha-1 Antitrypsin deficiency. It may also be used to monitor treatment or assess risk in certain inherited conditions.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re taking blood thinners, let your provider know before the test.

What the Results Mean

Lower than expected levels may indicate Alpha-1 Antitrypsin deficiency, which can increase your risk of lung or liver disease. Higher levels might be seen in certain liver conditions or during acute inflammation. Your provider will discuss results in the context of your overall health.

Common Conditions Linked to Results

Low levels of Alpha-1 Antitrypsin are strongly linked to Alpha-1 Antitrypsin deficiency, which can cause chronic lung diseases like emphysema or liver diseases like cirrhosis. High levels may be associated with conditions like acute hepatitis or certain liver disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What causes my Alpha-1 Antitrypsin levels to be low?
Low levels are often due to a genetic condition called Alpha-1 Antitrypsin deficiency. This can be inherited from family members. Other rare causes may include certain liver diseases or conditions that affect protein production.
How often should I get this test?
If you have a known deficiency, your provider may recommend regular monitoring, possibly every few years or more often if symptoms develop. If this is a one-time screening, follow-up depends on your symptoms and provider’s recommendations.
Can diet or supplements affect this test?
Dietary changes or supplements typically do not directly affect Alpha-1 Antitrypsin levels. However, if you’re taking medications that impact liver function, let your provider know as they may influence results indirectly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy