Serum/Plasma Protein Electrophoresis (Qualitative)
This test measures the types and amounts of proteins in your blood, often used to identify abnormalities in protein distribution that may signal conditions like inflammation, infections, or certain blood disorders.
["Helps diagnose and monitor conditions affecting protein balance in your blood."]
Key facts at a glance
- LOINC
- 28393-7
- Short code
- PAINFULJOINTS
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- reported-hiv-ssc
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Proteins Are Measured?
Electrophoresis separates blood proteins into fractions based on size and electrical charge. Key bands include albumin (fast-moving), alpha-globulins, beta-globulins, and gamma-globulins (antibodies). Abnormal bands may indicate conditions like multiple myeloma, chronic inflammation, or liver disease.
When Might You Need This Test?
Your doctor may order this test if you have symptoms like joint pain, unexplained weight loss, fatigue, or if they suspect conditions like rheumatoid arthritis, lupus, or certain cancers. It’s also used to monitor treatment progress for protein-related disorders.
How Is the Test Performed?
A blood sample is drawn, and proteins are separated using an electric current in a gel or paper medium. Results are visually interpreted for abnormal patterns or protein spikes.
What Does the Test Tell Us?
Abnormal results may show increased or decreased protein bands, which can point to conditions like monoclonal gammopathy (e.g., multiple myeloma), severe infections, or autoimmune diseases. Normal results suggest balanced protein levels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for diagnosing and managing conditions that alter protein production or distribution in the blood. For example, elevated gamma-globulins may indicate immune system dysfunction, while unusual bands could signal hidden cancers or metabolic disorders. Always discuss results with your healthcare provider for personalized interpretation.
Short name
Qualitative Protein Electrophoresis
Frequently asked questions
Why do doctors use qualitative protein electrophoresis for joint pain?
What does it mean if my test shows unusual protein bands?
Can this test replace other blood tests for joint pain?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy