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Pancreatic Islet Cell Antibody Screening (Serum)

Published: August 9, 2026Updated: August 17, 2026

This test measures antibodies that may indicate an autoimmune response targeting the cells in your pancreas, which could be linked to conditions like type 1 diabetes.

Quick summary

["This screening helps identify potential autoimmune pancreatic issues that may require further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
111041-0
Short code
Panc Islet Cell Ab Msmt Ser
Synonyms
Panc Islet Cell Ab Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies produced by your immune system that target the islet cells in your pancreas. These cells are responsible for producing insulin and other hormones. If your immune system mistakenly attacks these cells, it can lead to conditions like diabetes or other autoimmune disorders.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms such as unexplained weight loss, frequent urination, extreme thirst, or unexplained fatigue. It may also be used in cases where family history suggests a higher risk of autoimmune-related pancreatic disorders.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is processed to separate the serum, which is then tested for the presence of these antibodies. This process helps ensure accurate results without interference from other blood components.

What to Expect Before the Test

There are no special preparations needed for this test. You can eat and drink normally on the day of the test. If you are on any medications, inform your healthcare provider beforehand to avoid any potential interactions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Islet Cell Antibody (Screen)

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of antibodies against pancreatic islet cells, which may suggest an autoimmune response. This finding often leads to additional testing to confirm a diagnosis of conditions like type 1 diabetes or other autoimmune pancreatic disorders.
Can lifestyle changes help if this test is positive?
While lifestyle changes like a balanced diet, regular exercise, and stress management can support overall health, they may not directly address the autoimmune response detected by this test. Consult your healthcare provider for personalized advice based on your specific diagnosis.
How often will I need follow-up tests?
Follow-up testing frequency depends on your healthcare provider’s recommendations. If this test is part of an ongoing evaluation, they may schedule follow-ups based on your symptoms, test results, and overall health status to monitor progression or response to treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy