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Pancreatic Islet Cell Antibody Profile (Serum)

Published: August 9, 2026Updated: August 17, 2026

This blood test checks for antibodies that may indicate an autoimmune response targeting the cells in your pancreas, which could be linked to certain diabetes conditions.

Quick summary

["This screening helps identify potential autoimmune diabetes before symptoms appear."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
63571-4
Short code
Panc Islet Cell Ab pattern Ser IF-Imp
Synonyms
Panc Islet Cell Ab pattern Ser IF-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test measures the presence of antibodies (specifically islet cell antibodies) that attack insulin-producing cells in the pancreas. These antibodies can be detected in the blood and may signal an autoimmune process affecting insulin production.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms of diabetes (like frequent urination, extreme thirst, or unexplained weight loss), a family history of autoimmune diabetes, or if you’ve been diagnosed with another autoimmune condition.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The serum (liquid part of blood after clotting) is then tested for specific antibodies using an immunoassay method.

What Are Common Results?

A positive result means antibodies were found, which may suggest an autoimmune process affecting pancreatic function. A negative result means no detectable antibodies were found in this test.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Islet Cell Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of antibodies that may target pancreatic cells, which could be associated with autoimmune diabetes. This does not confirm diabetes yet but may signal a need for additional testing or monitoring.
How often should I get this test?
Your doctor will determine how often you need this test based on your symptoms, medical history, and other test results. Follow their guidance for follow-up.
Can lifestyle changes affect this test?
Lifestyle factors like diet, exercise, or stress may influence symptoms of diabetes but do not directly affect antibody test results. However, maintaining overall health supports overall diabetes management.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy