Pancreatic Islet Cell Antibody (Serum) – Quantitative

What Does This Test Measure?

The test detects specific antibodies (autoantibodies) that target proteins found in pancreatic islet cells. These antibodies are part of an immune response that can destroy insulin-producing cells, leading to diabetes. The presence of these antibodies suggests an autoimmune process rather than other causes of diabetes.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms of diabetes (such as frequent urination, extreme thirst, unexplained weight loss, or fatigue) or if you have a family history of type 1 diabetes. It may also be used in research or specialized evaluations for autoimmune conditions.

What Does a Positive Result Mean?

A positive result indicates the presence of islet cell antibodies, which may suggest an autoimmune process affecting insulin production. This does not confirm diabetes but supports further evaluation, including blood glucose testing or other autoimmune antibody panels.

What Does a Negative Result Mean?

A negative result means no detectable islet cell antibodies were found in your sample. While this does not rule out diabetes entirely, it suggests the autoimmune process may not be the primary cause in your case.