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Pancreatic Islet Cell Antibody Screening (Serum)

Published: August 9, 2026Updated: August 17, 2026

This test helps detect antibodies that may indicate an autoimmune response targeting the cells in your pancreas, which could be linked to conditions like type 1 diabetes.

Quick summary

["This screening may help identify early signs of autoimmune pancreatic issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
34652-8
Short code
Panc Islet Cell Ab Ser-sCnc
Synonyms
Panc Islet Cell Ab Ser-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like unexplained weight loss, frequent hunger, or unexplained fatigue, or if you have a family history of autoimmune diseases or type 1 diabetes. It may also be used as part of a broader evaluation for suspected autoimmune conditions affecting the pancreas.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm in a clinic or lab setting. The process usually takes a few minutes.

What the Test Measures

This test measures the presence of antibodies (specifically islet cell antibodies) in your blood. These antibodies are proteins that your immune system produces as a response to certain cells in the pancreas, which can be associated with autoimmune disorders.

How the Test Results Are Interpreted

Results are qualitative (positive or negative) rather than a specific numeric value. A positive result suggests the presence of these antibodies, which may warrant further evaluation by your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Islet Cell Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies that target pancreatic islet cells. This could suggest an autoimmune response, which may require further medical assessment to determine the next steps, such as additional testing or monitoring.
Will I need to take any medications if my results are positive?
If your results are positive, your healthcare provider will discuss next steps based on your symptoms, medical history, and further testing. Medications may be recommended to manage symptoms or slow disease progression, but this depends on individual circumstances.
Can this test be done at home?
No, this test requires a blood sample collected in a clinical setting. You’ll need to schedule an appointment with a healthcare provider or lab technician.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy