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Pancreatic Islet Cell Antibody (Serum) by Immunofluorescence

Published: August 9, 2026Updated: August 17, 2026

This test measures antibodies against pancreatic islet cells, which may indicate an autoimmune condition affecting the pancreas.

Quick summary

["This test helps diagnose autoimmune diabetes or other pancreatic disorders by detecting abnormal immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
45225-0
Short code
Panc Islet Cell CF Ab Titr Ser IF
Synonyms
Panc Islet Cell CF Ab Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (autoantibodies) that target proteins in pancreatic islet cells—the cells responsible for producing insulin. These antibodies may signal an autoimmune attack, such as in type 1 diabetes or other islet cell disorders.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, frequent urination, or unexplained hypoglycemia, especially if you have a family history of autoimmune diseases or diabetes.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The serum portion is separated and analyzed under a microscope to detect fluorescently labeled antibodies against islet cells.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications, recent illnesses, or pregnancy. Avoid alcohol for 24 hours before testing if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results suggest an autoimmune response targeting pancreatic islet cells, strongly supporting a diagnosis of type 1 diabetes or related conditions. While not definitive alone, it is often used alongside other tests (e.g., C-peptide levels) to assess autoimmune diabetes risk.

Short name

Islet Cell Antibody (Serum)

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of islet cell antibodies, which may mean your body’s immune system is attacking pancreatic cells. This is often seen in autoimmune diabetes but can also occur in other pancreatic disorders. Further testing is needed to confirm diagnosis and guide treatment.
What if my results are negative?
A negative result means no detectable islet cell antibodies were found in your sample. However, this does not rule out autoimmune diabetes entirely. Other tests (like C-peptide or genetic screening) may be needed to assess risk or rule out other conditions.
How often should I get this test?
This test is typically ordered as part of a diagnostic evaluation for suspected autoimmune diabetes or related conditions. Your provider will determine follow-up frequency based on your symptoms, medical history, and test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy