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Protein Electrophoresis, Serum (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood serum using electrophoresis, a method that separates proteins based on size and charge.

Quick summary

["Helps identify abnormal protein patterns that may signal conditions like multiple myeloma, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74452-4
Short code
PDW BldCo Auto
Synonyms
PDW BldCo Auto
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Protein Electrophoresis Used For?

Protein electrophoresis helps doctors detect and monitor conditions by analyzing how proteins move through a gel under an electric field. This can reveal unusual protein bands that might indicate diseases affecting protein production, such as certain cancers or metabolic disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The serum portion is then separated and placed on a gel. An electric current is applied to separate proteins by size and charge, creating distinct bands. These bands are later examined under light to identify any abnormal patterns.

Preparation and Sample Collection

No special preparation is needed for this test. You may eat and drink normally before your blood draw. If you have a history of bleeding disorders or are on blood thinners, inform your healthcare provider beforehand.

Possible Results and Interpretation

Results show different protein bands, including albumin, alpha-globulins, beta-globulins, and gamma-globulins. Abnormal bands or patterns may suggest conditions like multiple myeloma (excess monoclonal proteins), liver disease (altered albumin levels), or kidney disease (proteinuria). Your doctor will interpret the results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Protein electrophoresis is crucial for diagnosing and managing conditions such as multiple myeloma, where abnormal proteins (M proteins) appear. It can also identify liver or kidney dysfunction, infections, or inflammatory diseases by revealing shifts in protein composition. Early detection improves treatment planning and patient outcomes.

Short name

Serum Protein Electrophoresis

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have symptoms like unexplained weight loss, fatigue, frequent infections, or if they suspect conditions like multiple myeloma, liver disease, or kidney problems. It’s also used in follow-up care for patients with known protein-related disorders.
What are the common symptoms or conditions this test helps diagnose?
This test helps identify symptoms related to abnormal protein levels, such as bone pain (in multiple myeloma), swelling, or signs of organ dysfunction (like liver or kidney issues). It may also be used to monitor treatment progress in patients with known protein disorders.
How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your healthcare provider will discuss the results with you during a follow-up visit.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy