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Phenol-to-Creatinine Ratio, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

This test measures phenol relative to creatinine in urine collected over 24 hours. It may be used to assess urinary phenol levels, including possible exposure to phenol or benzene.

Quick summary

["A 24-hour urine phenol-to-creatinine ratio can help evaluate phenol exposure, particularly from benzene or phenol in the workplace."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44347-3
Short code
Phenol/Creat 24h Ur-sRto
Synonyms
Phenol/Creat 24h Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of phenol in urine relative to the amount of creatinine. Creatinine is a waste product produced at a fairly steady rate and is used to help account for differences in urine concentration.

Why might I need this test?

Urine phenol testing may be ordered for people who work with phenol, benzene, or related chemicals. It can also be used in occupational health evaluations when exposure to these substances is suspected.

How is the test performed?

Urine is collected into a special container for a full 24-hour period, and the amount of phenol and creatinine is measured. The results are combined to calculate the phenol-to-creatinine ratio.

How do I prepare for the test?

Follow the collection instructions provided by your clinician and collect all urine for exactly 24 hours. Tell your clinician about occupational, environmental, medication, or household chemical exposure; do not stop work or avoid products without medical guidance.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Phenol/Creatinine Ratio

Frequently asked questions

What does an elevated urine phenol-to-creatinine ratio mean?
It may suggest that your body is excreting more phenol than expected, which can occur after exposure to phenol, benzene, or certain related chemicals. Your clinician will interpret the result in the context of your exposure history and health.
Why is creatinine included in this test?
Urine concentration can vary from person to person and throughout the day. Comparing phenol with creatinine helps adjust for this variation, making results easier to compare and follow over time.
How is a 24-hour urine collection completed?
Usually, you empty your bladder at the start of the collection period, then collect every episode of urine for the next 24 hours in the provided container. The container is then returned for laboratory analysis, following your clinician's or laboratory's specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy