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Phenylpyruvate and Creatinine, Urine/Stool

Published: August 9, 2026Updated: August 16, 2026

Measures phenylpyruvate and creatinine in urine or stool to help evaluate phenylalanine metabolism, with urine creatinine helping account for urine concentration.

Quick summary

["This test can help identify problems with phenylalanine metabolism, particularly phenylketonuria, when interpreted with other clinical findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25126-4
Short code
Phenylpyruvate/Creat Ur-sRto
Synonyms
Phenylpyruvate/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures phenylpyruvate, a product formed when phenylalanine is broken down, along with creatinine. It may be performed on a urine or stool sample, depending on the test ordered.

Why might I need this test?

The test may be used as part of an evaluation for inherited disorders of phenylalanine metabolism, especially phenylketonuria. It may also be considered when blood phenylalanine results need additional evaluation.

How is the test performed?

A urine or stool sample is collected and analyzed in the laboratory. Urine creatinine is often measured to help account for variations in urine concentration.

How do I prepare for the test?

Follow any instructions provided by your healthcare professional or laboratory. The information needed for collection, timing, and diet may vary by specimen type and the reason for testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Phenylpyruvate and creatinine

Frequently asked questions

What does phenylpyruvate measure?
Phenylpyruvate is a product of phenylalanine metabolism. Its measurement can provide information about how the body is handling phenylalanine.
Why is creatinine measured with the urine sample?
Creatinine helps show how concentrated the urine is. This allows a low urine phenylpyruvate result to be distinguished from a low result caused by dilute urine.
Does this test diagnose phenylketonuria by itself?
No. Diagnosis and monitoring usually rely on blood phenylalanine testing and clinical assessment, with other tests used when needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy