Platelet Aggregation with Thrombin-Induced ATP Secretion (Whole Blood)
This test measures how platelets respond to thrombin by releasing ATP, a chemical that helps blood clot. It helps assess platelet function, especially in conditions where clotting may be impaired or excessive.
["This test evaluates platelet activity under controlled stimulation to check if they function normally in clotting."]
Key facts at a glance
- LOINC
- 56021-9
- Short code
- Platelet aggr int Bld Thrombin induced ATP secretion.1 U/mL-Imp
- Synonyms
- Platelet aggr int Bld Thrombin induced ATP secretion.1 U/mL-Imp
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 150
- Ref high
- 400
- Critical range
- 50 N/A – 1000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- thrombin-induced-atp-secretion-u-ml
- CPT
- 85049
- SNOMED
- 900000000000003003
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test evaluates platelet aggregation by measuring ATP release when platelets are exposed to thrombin, a natural protein that triggers clotting. ATP is a key signaling molecule in platelet activation. The response helps determine how effectively platelets can form clots when needed.
Why It’s Done
Doctors may order this test if you have symptoms like unexplained bruising, prolonged bleeding, or a history of clotting disorders. It can also be used to monitor treatments for bleeding or clotting conditions.
How It’s Performed
A small sample of your whole blood is taken and placed in a controlled environment where thrombin is added. The test measures ATP release over time to assess platelet function. No special preparation is needed, but fasting may be advised depending on the clinic.
What the Results Mean
Results typically compare your platelet response to a standard or reference range. A lower response may indicate poor platelet function, while an abnormal response could suggest underlying bleeding or clotting disorders.
Reference range
Adult: 150-400 x 10^9/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is particularly useful for diagnosing or monitoring conditions like von Willebrand disease, thrombocytopenia, or platelet dysfunction. It can also help guide treatment decisions for patients on blood thinners or those with suspected clotting disorders.
Short name
Thrombin-Induced ATP Release Test
Frequently asked questions
What causes abnormal platelet aggregation results?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy