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Protein Mass Concentration in Serum (e.g., Total Protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulins. Proteins are essential for maintaining fluid balance, supporting immunity, and transporting nutrients.

Quick summary

["Total protein helps assess hydration, liver function, and potential protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87638-3
Short code
p,p'-DDD Spec-mCnt
Synonyms
p,p'-DDD Spec-mCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like dehydration, liver disease, kidney problems, or malnutrition. It can also help monitor treatment responses in certain medical situations.

What Does the Result Mean?

Results may be lower than expected in cases of severe dehydration, kidney disease, or liver failure. Higher-than-normal levels might suggest conditions like multiple myeloma or severe burns.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The serum portion is separated and analyzed to determine protein concentration using standard laboratory methods.

What Are Common Causes of Abnormal Results?

Low protein levels can result from poor nutrition, kidney disease, or excessive fluid loss. High protein levels may indicate conditions like dehydration from vomiting/diarrhea or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels can serve as a general indicator of overall health status. Low levels may signal underlying issues requiring further investigation, such as protein-losing gastrointestinal disorders or immune deficiencies. High levels can sometimes reflect acute stress responses or specific medical conditions needing further diagnostic evaluation.

Short name

Total Serum Protein

Frequently asked questions

How often should I get this test?
Your doctor will determine the frequency based on your health status, symptoms, and medical history. Regular monitoring may be needed if you have chronic conditions like kidney disease or liver problems.
What do I need to do before the test?
No special preparation is usually required, but avoid heavy meals 2 hours before the blood draw. Inform your doctor about any medications or supplements you’re taking.
Can I drink water before the test?
Yes, you can drink water unless your doctor specifies otherwise. Hydration helps ensure a successful blood draw, but avoid excessive fluids right before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy