24-Hour Urinary Pregnanediol Excretion (Total)

Why This Test Is Done

Doctors may order this test to evaluate progesterone levels in pregnant women. It helps track fetal development, detect early pregnancy loss, or assess conditions like recurrent miscarriage or unexplained infertility. Pregnanediol levels can also indicate how well the placenta is functioning.

What to Expect Before the Test

You’ll collect all urine for a full 24-hour period, starting after you wake up and ending just before you wake up the next morning. Store the urine in a refrigerator or at room temperature, keeping it in a clean container. Do not add preservatives unless instructed.

How the Test Is Performed

The test involves measuring the total volume of urine collected and analyzing the sample for pregnanediol levels using a laboratory method like immunoassay or chromatography. The lab will calculate the total amount excreted over the 24-hour period.

What the Results Mean

Results are typically reported as the total amount of pregnanediol excreted (e.g., in micrograms or milligrams). Lower than expected levels may suggest issues like early pregnancy loss, placental dysfunction, or hormonal imbalances. Higher levels might indicate normal pregnancy progression or other conditions.