Pregnanediol and Creatinine, Urine or Stool
This test measures pregnanediol, a progesterone metabolite, alongside creatinine in a urine or stool sample. The exact sample type and ratio reporting should be confirmed.
["This test can help evaluate progesterone-related activity, but the sample type and results must be interpreted in your clinical context."]
Key facts at a glance
- LOINC
- 34359-0
- Short code
- Pregnanediol/Creat Ur-sRto
- Synonyms
- Pregnanediol/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Pregnanediol is a breakdown product of the hormone progesterone. This test measures pregnanediol together with creatinine, which may be used to adjust the pregnanediol result for sample concentration.
Why might I need this test?
A clinician may order this test to evaluate ovulation, fertility, or other aspects of reproductive hormone balance. It may also be used to follow progesterone-related changes over time.
How is the test performed?
A urine or stool sample is collected and tested in a laboratory. The order code appears to include both urine and stool, so confirm which specimen your clinician wants and whether the result will be reported as a pregnanediol-to-creatinine ratio.
How do I prepare for the test?
Follow the instructions provided with your order. If a urine test is ordered, mention whether it is a spot sample or a timed collection, such as a 24-hour collection; for stool, use the clean container supplied by the laboratory unless told otherwise.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A higher pregnanediol result may reflect increased progesterone production, which can occur around ovulation or during pregnancy. A lower result may be associated with reduced progesterone activity, although interpretation depends on the reason for testing and the point in the menstrual cycle. Creatinine is generally used for context or normalization, and stool results may require different interpretation than urine results.
Short name
Pregnanediol-Creatinine Test
Frequently asked questions
What does pregnanediol measure?
Why is creatinine measured with pregnanediol?
Should I provide a urine sample, a stool sample, or both?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy