Pregnanediol, 24-Hour Urine
Measures a progesterone metabolite in urine collected for 24 hours to help evaluate hormone production and certain reproductive or pregnancy-related concerns.
This test measures how much pregnanediol your body is releasing over a full day.
Key facts at a glance
- LOINC
- 82895-4
- Short code
- Pregnanediol/THE+THF+5a-THF 24h Ur-sRto
- Synonyms
- Pregnanediol/THE+THF+5a-THF 24h Ur-sRto
- Category
- liver
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Pregnanediol is a metabolite formed when your body breaks down progesterone. This test measures pregnanediol in all urine collected during a 24-hour period. It may be used with other tests to evaluate hormone production, ovulation, or pregnancy-related status.
Why might I need this test?
A clinician may order this test when evaluating menstrual or fertility concerns, suspected ovulation, or progesterone production. It has also been used in some assessments of pregnancy and placental function, although other hormone tests are often used alongside it.
How is the test performed?
You usually collect all urine for exactly 24 hours into a special container provided by the laboratory. Record the time the collection begins and ends, and bring the container to the laboratory as instructed. The laboratory then measures the pregnanediol in the collected sample.
How do I prepare for the test?
Follow your laboratory's collection instructions carefully, since an incomplete or incorrectly timed collection can affect the result. Tell the clinician if you are pregnant, taking hormones or other medicines, or recently finished a fertility treatment. Ask whether the container should be refrigerated and how it should be transported.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Pregnanediol reflects the body's production and metabolism of progesterone, but the level can vary with pregnancy, menstrual-cycle timing, age, medications, and other factors. A lower result may occur when progesterone production is reduced, while a higher result may reflect increased hormone production, pregnancy, or hormone supplementation. Results should be interpreted by a clinician together with symptoms, medical history, and other laboratory tests.
Short name
24-Hour Urine Pregnanediol
Frequently asked questions
Why is a 24-hour urine collection needed?
Does this test require fasting?
What if part of the urine collection is missed?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy