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Prenatal Diagnostic Screening Panel (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test may include blood tests to check for certain markers that can help identify risks for genetic conditions or chromosomal abnormalities during pregnancy.

Quick summary

["Early screening for potential pregnancy health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89498-0
Short code
Prenatal Dx
Synonyms
Prenatal Dx
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Prenatal screening often assesses levels of specific substances in your blood, such as proteins or hormones, that may indicate higher or lower risks for conditions like Down syndrome, neural tube defects, or other genetic factors. Some tests may also evaluate blood type and Rh factor for compatibility.

Why Is This Test Done?

Your healthcare provider may recommend this test during early pregnancy to help determine if further diagnostic testing is needed. It’s not a definitive diagnosis but can provide important information to guide next steps.

How Is the Sample Collected?

A blood sample is drawn from a vein in your arm. You may feel a small pinch, but it usually doesn’t cause discomfort afterward. The sample is sent to a lab for analysis.

What Are the Possible Results?

Results may show a range of values for different markers. A higher or lower result than expected could signal an increased risk for certain conditions, prompting additional testing or monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Prenatal Screening

Frequently asked questions

What Are My Next Steps If I Get a Screening Result?
If your screening result suggests an increased risk, your provider may discuss additional testing options with you. They’ll also explain how to proceed based on your personal and family medical history.
How Often Should I Get This Test?
This test is typically done once during early pregnancy, usually between 10 and 14 weeks. Your provider will determine if repeat screening is needed based on your results and health status.
Does This Test Include Genetic Counseling?
No, this test itself does not include genetic counseling. However, your healthcare provider or a genetic counselor can discuss the results and next steps with you in detail.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy