Prenatal Screening for Chromosomal and Genetic Conditions via Cell-Free DNA
This test analyzes a small amount of DNA found in your blood that comes from your baby, helping identify certain genetic or chromosomal conditions during pregnancy.
["A simple blood test to check for potential genetic risks before birth."]
Key facts at a glance
- LOINC
- 104489-0
- Short code
- Prenatal screening rprt Doc
- Synonyms
- Prenatal screening rprt Doc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 86592
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
How the Test Works
A tiny sample of your blood is taken to detect circulating cell-free DNA (cfDNA) from your baby. Advanced laboratory techniques identify specific genetic markers associated with chromosomal abnormalities or genetic conditions.
What to Expect Before the Test
No special preparation is needed. You may have a standard blood draw, similar to other blood tests. Your healthcare provider will explain the process and answer any questions you have.
What the Results Mean
Results provide a statistical likelihood (risk) rather than a definitive diagnosis. They help guide further testing if needed, such as amniocentesis or chorionic villus sampling (CVS). Discuss results with your healthcare provider to understand implications for your pregnancy.
Common Conditions Detected
This screening can help detect conditions like Down syndrome, Edwards syndrome, Patau syndrome, and certain genetic disorders. It does not screen for all possible conditions and may not detect every risk.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Prenatal screening is an important tool for early detection of potential genetic or chromosomal issues. It allows healthcare providers to offer informed decisions about next steps, such as additional diagnostic testing if results suggest higher risk. It does not replace other prenatal care, including regular ultrasounds and blood tests.
Frequently asked questions
Why was I asked to take this test?
What does a positive or high-risk result mean?
Can I choose not to have this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy