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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, nutritional status, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
65839-3
Short code
PRINCIPALRESULTINTERPRETERTITLE
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions like malnutrition, liver disease, kidney problems, or certain immune disorders. It can also help monitor treatment progress for conditions affecting protein production or breakdown.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader panel. Bring any medications you’re currently taking to your doctor’s office.

How the Test Works

A healthcare provider will draw blood from a vein in your arm. The blood sample is sent to a lab, where it’s analyzed to measure the total protein content in your serum.

What the Results Mean

Results are typically reported in grams per deciliter (g/dL). Low levels may suggest malnutrition, liver disease, or kidney issues, while high levels could indicate dehydration, inflammation, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues. For example, low protein may reflect poor nutrient absorption or chronic disease, while elevated levels could indicate conditions like multiple myeloma or severe dehydration. Always discuss results with your doctor for personalized interpretation.

Short name

Total Protein

Frequently asked questions

How long does it take to get my results?
Results are usually available within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once they’re ready to review them with you.
Can I eat or drink before this test?
If your test is standalone, you can eat and drink normally. However, if it’s part of a fasting panel, follow your doctor’s instructions—typically avoiding food for 8–12 hours before drawing blood.
What if my protein levels are out of the normal range?
If your results are abnormal, your doctor may recommend further testing or adjustments to your treatment plan. They’ll explain what the findings mean in the context of your health and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy