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Protein Electrophoresis (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, including albumin and globulins, which can help identify conditions affecting protein balance.

Quick summary

["Protein electrophoresis helps diagnose and monitor conditions like kidney disease, liver disorders, and certain immune system issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18524-9
Short code
P-R interval L-II
Synonyms
P-R interval L-II
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check for abnormal protein levels that could signal conditions such as multiple myeloma, liver disease, or kidney problems. It’s also used to monitor treatment progress for certain blood disorders.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Bring any medications or questions to your appointment.

How the Test Works

A small blood sample is taken from your arm and sent to a lab. The serum is separated and placed on a gel where an electric current causes proteins to move based on their size and charge, creating distinct bands.

Interpreting Results

Results show the distribution of proteins across different regions (e.g., albumin, alpha, beta, gamma globulins). Abnormal patterns may indicate inflammation, infections, or genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

What causes abnormal protein electrophoresis results?
Abnormal results may be linked to conditions such as kidney disease, liver problems, infections, autoimmune disorders, or certain cancers. Your doctor will consider your symptoms and medical history to interpret findings.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss findings.
Can diet affect protein electrophoresis results?
Dietary changes alone won’t alter protein electrophoresis results, but fasting requirements may influence timing. Avoid excessive alcohol or certain medications that could affect protein levels before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy