: Prescription Opioid Testing
: This test looks for prescription opioid medications or their breakdown products in a body sample. It is used to see whether a prescribed opioid is present, for example in medication monitoring or drug testing.
[": A prescription opioid test detects prescribed opioid drugs or their metabolites in a sample, but the exact drugs covered depend on the specific test panel used."]
Key facts at a glance
- LOINC
- 106717-2
- Short code
- PRNOPIOID
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- cms-assessment
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
: What This Test Measures
: Opioids are a group of medicines used mainly for pain relief, and they include drugs such as morphine, codeine, oxycodone, and hydrocodone. When you take an opioid, your body breaks it down into related substances called metabolites, and a laboratory can look for the drug and these metabolites in a sample. The compressed test name does not specify the sample type or the exact detection method, so the precise list of drugs detected depends on how the test is ordered by your clinician.
: Why It Is Ordered
: A healthcare provider may order this kind of test to check that a prescribed opioid is being taken as directed, to monitor a pain-management plan, or as part of broader drug testing. It is not a measure of pain control or a judgment about your care; it is one piece of information your provider uses alongside your history and other results.
: How the Sample Is Collected
: Depending on the test your provider orders, the sample may be blood, urine, or another specimen, and collection is usually a routine blood draw or urine sample. The slug does not state the specimen, so ask your provider or laboratory which sample is being used and whether any special preparation is needed.
: What Results Mean
: A result may be reported as positive or negative, or as a detected level, and a positive result generally means the drug or a related substance was found. Results must be interpreted by your provider, because many factors can affect them, including the dose, how recently a medicine was taken, and other medications. The exact reporting format and any decision limits depend on the specific assay used.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
: Rx Opioid Screen
Frequently asked questions
: Does a positive result mean I misused my medication?
: Can other medicines affect the result?
: What sample is used for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy