Protein Electrophoresis, Serum
This test measures the different types of proteins in your blood, including albumin and globulins, which help your body function properly. It’s often used to check for conditions like kidney disease, liver problems, or certain blood disorders.
["This test helps identify protein imbalances that may signal underlying health issues."]
Key facts at a glance
- LOINC
- 25742-8
- Short code
- Pro Frg1+2 SerPl-sCnc
- Synonyms
- Pro Frg1+2 SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Doctors may order a serum protein electrophoresis to diagnose or monitor conditions such as multiple myeloma, Waldenström macroglobulinemia, or other protein-related disorders. It can also help evaluate kidney function, liver disease, or autoimmune conditions by analyzing protein patterns in your blood.
How the Test Works
A small blood sample is taken from your arm and sent to a lab. The serum (liquid part of blood after clotting) is then separated and run through an electric field to separate proteins based on size and charge. Different bands appear on a gel, each representing a type of protein.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Wear comfortable clothing and bring any medications you’re currently taking.
What to Expect During the Test
The test involves a quick blood draw from a vein in your arm. You may feel a slight pinch, but it’s over quickly. The blood sample is processed and sent to a lab for analysis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal protein patterns can indicate conditions like multiple myeloma (where abnormal proteins, such as monoclonal gammopathy, are produced), kidney disease (where protein levels may be altered), or liver disease (where protein synthesis may be impaired). It can also help detect autoimmune disorders or infections.
Short name
Serum Protein Electrophoresis
Frequently asked questions
What Does a High or Low Protein Level Mean?
How Often Should I Get This Test?
Can Diet or Medications Affect This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy