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Progesterone, Serum (15-Hydroxyprogesterone)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of 15-hydroxyprogesterone, a metabolite of progesterone, in your blood. It’s often used to help diagnose conditions related to hormonal imbalances, particularly in reproductive health.

Quick summary

["This test helps assess hormone-related disorders, especially in pregnancy or fertility evaluations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17484-7
Short code
Progest 1.5h p chal SerPl-mCnc
Synonyms
Progest 1.5h p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate abnormal menstrual cycles, infertility, or to investigate symptoms like irregular periods, pelvic pain, or signs of hormonal imbalances. It can also be used during pregnancy to check for conditions like pregnancy loss or complications.

What Does the Result Mean?

Results may vary depending on your medical history and symptoms. High levels might suggest certain hormonal disorders, while low levels could indicate issues with hormone production or metabolism. Your doctor will interpret the results in the context of your overall health.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The sample is processed to separate serum (the liquid part of blood without clotting factors) for testing. This test is typically done after an overnight fast for consistency.

Common Conditions Monitored

This test is often used in conjunction with other hormone tests to diagnose or monitor conditions such as congenital adrenal hyperplasia (CAH), polycystic ovary syndrome (PCOS), or other hormonal imbalances affecting fertility or pregnancy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

15-Hydroxyprogesterone

Frequently asked questions

What could cause abnormal results?
Abnormal results may be linked to genetic conditions, hormonal disorders, or other underlying health issues. Always discuss your results with your healthcare provider, as they will consider your full medical history and symptoms to provide accurate guidance.
How often should I get this test?
The frequency depends on your medical needs. Your healthcare provider will determine how often to repeat this test based on your diagnosis, symptoms, or treatment plan.
Can I take anything before the test?
For best accuracy, follow your provider’s instructions, which may include fasting or avoiding certain medications. Avoid smoking or consuming alcohol before the test, as these can affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy