Skip to content

Progesterone, Serum (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone hormone in your blood, which plays a key role in reproductive health and hormone regulation.

Quick summary

["Progesterone levels help track fertility, pregnancy, and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17486-2
Short code
Progest 2h p chal SerPl-mCnc
Synonyms
Progest 2h p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to diagnose or monitor conditions such as hormonal imbalances, fertility issues, ovarian cysts, or to assess pregnancy (e.g., during early pregnancy or miscarriage evaluation). It can also help evaluate hormone therapy responses or evaluate symptoms like irregular periods or breast tenderness.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Wear comfortable clothing and plan to rest afterward, as drawing blood can make you lightheaded.

What Happens During the Test?

A healthcare professional will insert a needle into a vein in your arm to collect a blood sample. You may feel a brief pinch, but the process is quick. The blood is then sent to a lab for analysis.

What Does the Test Result Mean?

Results are interpreted by your provider based on your medical history, symptoms, and other tests. Abnormal levels may indicate conditions like polycystic ovary syndrome (PCOS), ovarian tumors, or hormonal deficiencies. Your provider will discuss findings with you in detail.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Progesterone plays a critical role in reproductive cycles, pregnancy maintenance, and menstrual regulation. Low levels may signal ovulation issues, while elevated levels could suggest tumors or other endocrine disorders. This test is often used alongside other hormone assessments for comprehensive evaluation.

Short name

Serum Progesterone Level

Frequently asked questions

What does a high or low progesterone level typically indicate?
A high level may suggest conditions like ovarian cysts, pregnancy, or hormonal tumors, while low levels could indicate ovulation problems, early pregnancy loss, or hormonal imbalances. Your provider will interpret results in the context of your health.
Can diet or supplements affect progesterone levels?
Certain foods, supplements (like omega-3s or phytoestrogens), and medications (e.g., birth control) may influence hormone levels. Always discuss dietary or supplement changes with your provider before testing.
How often should I get this test?
Frequency depends on your medical needs. Your provider may recommend testing during ovulation tracking, fertility evaluations, or monitoring hormone therapy. Follow their guidance for the best timing and intervals.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy