Progesterone, 24-Hour Urinary Metabolite Profile (Total)
This test measures the total amount of progesterone metabolites excreted in your urine over a 24-hour period. Progesterone is a hormone involved in reproductive health and menstrual cycles.
["Understanding your progesterone metabolite levels can help assess reproductive function and hormone balance."]
Key facts at a glance
- LOINC
- 12821-5
- Short code
- Progest 30M p chal SerPl-mCnc
- Synonyms
- Progest 30M p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 80
- Ref high
- 200
- Critical range
- 20 N/A – 400 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 84436
- SNOMED
- 302346007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like irregular menstrual periods, fertility issues, or signs of hormonal imbalances. It can also be used to monitor conditions like polycystic ovary syndrome (PCOS) or evaluate hormone therapy responses.
What to Expect Before the Test
You’ll typically provide a 24-hour urine collection starting after your first morning urine void. Follow your provider’s instructions carefully to ensure accurate results, including timing and storage of samples.
What the Test Measures
The test quantifies the total excretion of progesterone metabolites in your urine. This reflects your body’s ongoing progesterone production, which can be influenced by menstrual cycles, pregnancy, or medical treatments.
How the Results Are Interpreted
Results are compared to general reference ranges for healthy individuals, though specific ranges may vary by lab. Elevated levels might suggest conditions like ovarian tumors or certain hormonal therapies, while low levels could indicate issues like premature ovarian insufficiency or hormonal deficiencies.
Reference range
Adult: 80-200 ng/dLN/A
Take your thyroid medication after the blood draw if applicable. No fasting required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Progesterone metabolite levels are critical for diagnosing and managing reproductive disorders. High levels may indicate abnormal hormone production or tumors, while low levels can signal hormonal imbalances affecting fertility, menstrual cycles, or pregnancy. This test helps guide treatment decisions for conditions like PCOS, endometriosis, or hormone replacement therapy.
Frequently asked questions
What does a 24-hour urine test for progesterone metabolites involve?
How often is this test typically repeated?
Can lifestyle or diet affect this test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy