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Progesterone, Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, in your blood. Progesterone plays a key role in regulating the menstrual cycle, pregnancy, and other reproductive functions.

Quick summary

["Progesterone levels help assess fertility, ovulation, and potential pregnancy complications."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96423-9
Short code
Progest DBS-mCnc
Synonyms
Progest DBS-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test to evaluate reproductive health, diagnose conditions like polycystic ovary syndrome (PCOS), check for ovulation issues, or monitor pregnancy-related hormone changes. It might also be used in fertility treatments or to investigate symptoms such as irregular periods, missed periods, or unexplained infertility.

When to Expect Results

Results are typically available within 1 to 3 business days, depending on your lab. Follow-up with your healthcare provider to discuss the findings and next steps.

Common Reasons for Testing

Progesterone testing is often done during the luteal phase of the menstrual cycle (around days 21–25 of a 28-day cycle) to confirm ovulation. It can also be checked during early pregnancy to assess uterine lining preparation or to diagnose conditions like luteal phase deficiency.

Sample Preparation and Timing

For best accuracy, blood should be drawn during the late follicular or early luteal phase of your menstrual cycle. Avoid testing during menstruation or shortly after ovulation. Fast for 8–12 hours before the test if instructed by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Progesterone

Frequently asked questions

What Might High or Low Levels Indicate?
High progesterone levels may suggest conditions like ovarian tumors, Cushing’s syndrome, or certain medications that increase hormone production. Low levels could indicate ovulation issues, hormonal imbalances, or conditions like premature ovarian insufficiency.
How Might Results Affect My Treatment?
Results can guide decisions about fertility treatments, hormone therapy, or further diagnostic testing. For example, low progesterone might prompt additional evaluations or treatments to support ovulation or pregnancy.
How Often Should I Get This Test?
Frequency depends on your health goals. If monitoring fertility, your provider may recommend testing during specific cycles. During pregnancy, levels are checked at certain stages to ensure normal development.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy