Skip to content

Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced primarily by the ovaries during the menstrual cycle and pregnancy. Progesterone helps regulate the menstrual cycle and supports early pregnancy.

Quick summary

["Progesterone levels help track ovulation, fertility, and potential pregnancy health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63885-8
Short code
Progestin Ys CTS
Synonyms
Progestin Ys CTS
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
california-teachers-study
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order a serum progesterone test to evaluate reproductive health, diagnose fertility issues, check for hormonal imbalances, or monitor conditions like polycystic ovary syndrome (PCOS), menstrual irregularities, or pregnancy complications. It can also be used during fertility treatments to assess ovarian function.

When to Expect Results

Results are typically available within 1 to 3 business days after your blood sample is drawn. Your provider will discuss the findings with you during your follow-up visit.

What to Expect During the Test

A blood sample will be taken from a vein in your arm by a healthcare professional. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. No special preparation is needed, though fasting may be advised depending on the clinical context.

Common Reasons for Abnormal Results

Progesterone levels can vary widely depending on the phase of the menstrual cycle or pregnancy. Low levels may indicate issues like ovarian dysfunction, hormonal imbalances, or early pregnancy loss. High levels might suggest conditions like ovarian tumors or certain medications that affect hormone production.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Progesterone

Frequently asked questions

How long does it take for progesterone levels to change after ovulation?
Progesterone levels typically rise after ovulation and peak around 10–14 days after ovulation. They remain elevated during early pregnancy to support the uterine lining. Your provider will consider your cycle phase or pregnancy status when interpreting results.
Can diet or supplements affect progesterone test results?
Some supplements, like evening primrose oil or black cohosh, may influence hormone levels. Avoiding certain supplements for a few days before testing can help ensure accurate results. Always discuss your medications or supplements with your provider before the test.
Is there any pain or discomfort associated with this test?
Most people experience only mild discomfort or a brief pinch during blood draw. Most people recover quickly without complications. If you have a blood clotting disorder or are on blood thinners, let your provider know before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy