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Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, in your blood serum. Progesterone plays a key role in regulating menstrual cycles, pregnancy, and overall reproductive health.

Quick summary

["Progesterone levels help assess fertility, pregnancy timing, and potential hormone-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110647-5
Short code
Progest Msmt SerPl
Synonyms
Progest Msmt SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate reproductive health, diagnose conditions like polycystic ovary syndrome (PCOS), check for pregnancy complications, or monitor hormone therapy. It can also help determine the timing of ovulation or assess reasons for missed periods or infertility.

What Does the Test Measure?

Progesterone is a steroid hormone that helps prepare the uterus for pregnancy and supports early pregnancy. It peaks around the time of ovulation and declines if pregnancy does not occur. The test measures its concentration in your blood serum.

Sample Collection and Preparation

A blood sample is collected from a vein, usually in your arm. The blood is then separated into serum (the liquid part after clotting) for testing. This test does not require fasting, but follow your provider’s instructions for any specific preparation.

What Are Common Results and Interpretation?

Results are typically reported in nanograms per milliliter (ng/mL) or picograms per milliliter (pg/mL), but reference ranges can vary by lab and clinical context. Higher or lower levels may indicate specific health concerns that your provider will discuss with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Progesterone levels are crucial for diagnosing and managing reproductive disorders. Low levels may suggest ovulation issues, hormonal imbalances, or early pregnancy loss. Elevated levels might indicate conditions like ovarian tumors or certain endocrine disorders. Your provider will interpret results in the context of your medical history and symptoms.

Short name

Serum Progesterone

Frequently asked questions

What causes abnormal progesterone levels?
Abnormal progesterone levels can result from conditions like polycystic ovary syndrome (PCOS), ovarian cysts, premature ovarian failure, or certain medications that affect hormone production. They may also appear in pregnancy-related complications or during hormone replacement therapy.
How often should I get this test?
The frequency depends on your medical needs. Your healthcare provider will determine how often to test based on your symptoms, medical history, and treatment plan. For example, it might be done monthly during ovulation monitoring or less frequently for routine reproductive health checks.
Can lifestyle changes affect progesterone levels?
Yes, lifestyle factors such as stress, poor sleep, obesity, and certain medications (like birth control or antidepressants) can influence progesterone levels. Maintaining a balanced diet, managing stress, and staying physically active may support hormonal balance, but always consult your provider for personalized advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy