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Progesterone, Serum or Plasma Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, in your blood. Progesterone plays a key role in the menstrual cycle, pregnancy, and overall reproductive health.

Quick summary

["Progesterone levels help assess fertility, ovulation, and potential pregnancy complications."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35223-7
Short code
Progest SerPl-msCnc
Synonyms
Progest SerPl-msCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test to evaluate reproductive health, diagnose conditions like polycystic ovary syndrome (PCOS), check for ovulation, or monitor pregnancy-related issues. It could also be used in fertility treatments or to investigate unexplained menstrual irregularities.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s drawn from fasting serum. If you’re taking hormonal medications, let your provider know. Avoid smoking or caffeine for 30 minutes before the draw.

During the Test Process

A small needle will be inserted into a vein in your arm to collect blood. You may feel a brief pinch, but the process is quick. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results are typically reported in nanograms per milliliter (ng/mL) or picograms per milliliter (pg/mL), but exact ranges vary by lab. Your provider will interpret results in the context of your health history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Progesterone levels can indicate ovulation timing, help diagnose hormonal imbalances, or assess risks for conditions like miscarriage or preterm labor. Low levels may suggest ovulatory dysfunction, while high levels could be linked to certain cancers or pregnancy complications. Always discuss results with your healthcare provider.

Short name

Progesterone Level

Frequently asked questions

What causes abnormal progesterone levels?
Abnormal progesterone levels can result from conditions like PCOS, ovarian cysts, thyroid disorders, or certain medications. They may also appear in pregnancy-related complications or rare hormonal cancers. Lifestyle factors, such as stress or obesity, can sometimes influence hormone levels too.
How often should I get this test?
Frequency depends on your medical needs. Your provider may order it once or multiple times during a menstrual cycle, pregnancy, or fertility evaluation. Follow their guidance—do not schedule it without approval.
Can diet or supplements affect progesterone levels?
Yes, certain foods, herbs, or supplements (like soy, licorice, or black cohosh) may influence hormone levels. Avoiding alcohol, caffeine, and smoking before testing can help ensure more accurate results. Always check with your provider before taking new supplements.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy