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Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, in your blood. Progesterone helps regulate your menstrual cycle and supports pregnancy.

Quick summary

["Progesterone levels can help diagnose fertility issues, track ovulation, or monitor pregnancy health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33853-3
Short code
Progest sp1 p chal SerPl-sCnc
Synonyms
Progest sp1 p chal SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’re experiencing irregular periods, trouble getting pregnant, or if you’re undergoing fertility treatments. It can also be used to check for conditions like polycystic ovary syndrome (PCOS) or to evaluate early pregnancy.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your lab requires it. Bring any medications you’re taking to your appointment.

How the Test Works

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab where it’s analyzed to measure progesterone concentration using a sensitive immunoassay method.

What the Results Mean

Results can vary based on your cycle phase, pregnancy status, or medical condition. Your provider will interpret the results in the context of your health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Progesterone’s Role in Health

Short name

Serum Progesterone

Frequently asked questions

How can I prepare for this test if I’m on hormonal birth control?
If you’re on hormonal birth control, your levels may be lower than expected, as these medications suppress natural hormone production. Ask your provider if they recommend waiting until you’re off birth control before testing or if they can adjust the timing of your cycle for more accurate results.
What if my progesterone levels are outside of what’s considered normal?
Abnormally low progesterone could indicate issues like ovarian dysfunction or early pregnancy loss, while high levels might suggest conditions like ovarian cysts or certain tumors. Your provider will discuss these findings with you and may recommend further testing or treatment options.
Can I drink alcohol before this test?
Alcohol can sometimes affect hormone levels, but it’s not typically restricted for this test unless your lab has specific guidelines. If you’re unsure, check with your provider or lab staff before your appointment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy