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Serum/plasma progesterone concentration (qualitative/confirmatory screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, uterus, and adrenal glands, typically in blood serum or plasma. Progesterone plays a key role in reproductive health, pregnancy, and menstrual cycles.

Quick summary

["Progesterone levels help assess reproductive function, fertility, and potential pregnancy health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25508-3
Short code
Progest sp2 p chal SerPl-sCnc
Synonyms
Progest sp2 p chal SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test to evaluate hormonal balance, diagnose conditions like polycystic ovary syndrome (PCOS), check for pregnancy-related issues, or monitor treatment for hormonal imbalances. It can also be used during fertility evaluations or to assess menstrual irregularities.

What Does a Progesterone Test Measure?

Progesterone is a steroid hormone that helps prepare the uterus for pregnancy by thickening the uterine lining. It also plays a role in regulating the menstrual cycle and suppressing ovulation. This test measures its concentration in your blood, which can vary depending on your menstrual cycle phase or other health factors.

Sample Preparation and Testing Process

A blood sample is collected from a vein in your arm. The sample is then processed to separate serum or plasma, which is sent to a lab for analysis. The test is typically performed using immunoassay methods to detect progesterone levels accurately.

What Are Common Reasons for Abnormal Results?

Low progesterone levels might suggest issues like premature ovarian insufficiency, hormonal imbalances, or conditions affecting ovulation. High levels could indicate pregnancy, certain tumors, or other hormonal disorders. Results should always be interpreted by a healthcare provider in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Progesterone Level (Serum/Plasma)

Frequently asked questions

What factors could affect my test results?
Several factors may influence progesterone levels, including your menstrual cycle phase (e.g., mid-luteal phase is typically when levels are highest), pregnancy, certain medications (like birth control or steroids), chronic illnesses, and stress. It’s important to discuss your cycle timing and any medications with your provider before the test.
How soon will I get my results, and what does that mean?
Results are usually available within 1–3 business days, depending on the lab. Your provider will explain what the results mean in relation to your health. If results are outside expected ranges, further testing or evaluation may be needed to determine the cause.
Can I take anything special before this test?
No special preparations are usually needed, but avoid smoking, excessive caffeine, or alcohol 24 hours before the test. If you’re taking hormonal medications, let your provider know. If you’re pregnant or suspect pregnancy, inform your healthcare provider before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy