Progesterone, Serum (High-Performance Liquid Chromatography)

Why Is This Test Done?

Your healthcare provider may order this test to evaluate hormone balance, diagnose conditions like polycystic ovary syndrome (PCOS), assess fertility, or monitor pregnancy-related hormone changes. It can also help diagnose hormonal imbalances or evaluate symptoms such as irregular periods, menstrual irregularities, or signs of ovarian or adrenal issues.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed. Bring any medications you’re currently taking, as some may affect results. Avoid smoking or consuming alcohol for a few hours before the draw.

What Happens During the Test?

A healthcare professional will collect a blood sample from a vein in your arm. You may feel a slight pinch, but the process is quick. The sample is sent to a lab for analysis using liquid chromatography to measure progesterone concentration.

What the Results Mean

Results are compared to standard reference ranges, but individual needs vary. Low levels may suggest issues like ovarian dysfunction or early pregnancy, while high levels could indicate conditions like ovarian cysts or certain tumors. Your provider will interpret results in the context of your medical history and symptoms.