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Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced mainly by the ovaries, in your blood. It helps assess reproductive health, fertility, and potential hormone-related conditions.

Quick summary

["Progesterone levels can guide treatment for menstrual irregularities, pregnancy support, or hormone-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12818-1
Short code
Progest sp5 p chal SerPl-mCnc
Synonyms
Progest sp5 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate ovulation, diagnose conditions like polycystic ovary syndrome (PCOS), check for pregnancy complications, or monitor hormone therapy. It’s also used in fertility treatments or to assess hormonal imbalances during menstrual cycles.

When Might You Need This Test?

You might need this test if you have irregular periods, symptoms of hormonal imbalances (like heavy bleeding or missed periods), suspected pregnancy complications, or if you’re undergoing fertility treatments. It could also be part of routine monitoring for certain reproductive health conditions.

What to Expect Before the Test

No special preparation is usually needed, but your provider may advise timing it around your menstrual cycle (e.g., mid-luteal phase for ovulation assessment). Avoid alcohol or certain medications that could affect results for 24 hours before testing.

What Happens During the Test?

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab for analysis. The process takes about 15 minutes, and you can resume normal activities afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Progesterone levels help diagnose ovulation disorders, evaluate pregnancy viability, assess hormone-related symptoms, and guide treatment for conditions like endometriosis or menopause. Low levels may indicate issues with ovulation or luteal phase defects, while elevated levels could signal tumors or other hormonal imbalances.

Short name

Serum Progesterone

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss the findings with you during your follow-up visit.
What do abnormal results mean?
Abnormally low progesterone could suggest ovulation problems, early menopause, or certain medications affecting hormone production. Abnormally high levels might indicate hormonal tumors, pregnancy complications, or other rare conditions. Always discuss results with your provider for personalized interpretation.
Can diet or supplements affect this test?
Some supplements (like soy or phytoestrogens) or medications (e.g., birth control, steroids) may influence hormone levels. Avoid alcohol and certain medications for 24 hours before testing to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy