Skip to content

Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, in your blood. Progesterone plays a key role in the menstrual cycle, pregnancy, and overall reproductive health.

Quick summary

["Understanding your progesterone levels helps track ovulation, fertility, and potential hormonal imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17489-6
Short code
Progest sp8 p chal SerPl-mCnc
Synonyms
Progest sp8 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a serum progesterone test to diagnose fertility issues, evaluate menstrual cycle irregularities, check for hormonal imbalances, or monitor conditions like endometriosis or polycystic ovary syndrome (PCOS). It can also be used during pregnancy to assess early pregnancy viability or detect complications like miscarriage risk.

What to Expect Before the Test

No special preparation is usually needed, but your doctor may advise timing the test around your menstrual cycle (e.g., mid-luteal phase for fertility evaluation). Avoid alcohol or certain medications that could affect results for 24 hours before testing.

How the Test Is Performed

A blood sample is drawn from a vein, typically in your arm, by a healthcare professional. The blood is sent to a lab where it is analyzed to measure progesterone concentration using an immunoassay method.

What the Results Mean

Results are reported in mass concentration units (e.g., ng/mL or pmol/L), but your doctor will interpret them in the context of your medical history and symptoms. Low or high levels may signal underlying health concerns that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Progesterone levels help identify ovulation timing, assess fertility, diagnose hormonal disorders, and monitor pregnancy. Abnormal results may indicate conditions like ovarian dysfunction, thyroid disorders, or adrenal issues. Your doctor will discuss findings with you based on your symptoms and medical history.

Short name

Serum Progesterone Level

Frequently asked questions

What causes progesterone levels to be low?
Low progesterone levels can result from conditions like premature ovarian insufficiency, polycystic ovary syndrome (PCOS), thyroid disorders, or certain medications. Lifestyle factors, such as stress or poor nutrition, may also play a role. If you suspect low progesterone, discuss symptoms like irregular periods, infertility, or fatigue with your healthcare provider.
How often should I get this test?
The frequency depends on your health goals. For fertility evaluation, tests may be done multiple times during your cycle. If monitoring a chronic condition, your doctor will determine the best schedule. Follow-up tests are often recommended if initial results are abnormal or if symptoms persist.
Can diet or supplements affect progesterone levels?
Yes, certain foods, vitamins, and supplements can influence hormone levels. For example, omega-3 fatty acids, vitamin D, and magnesium may support hormonal balance, while excessive caffeine or alcohol can disrupt cycles. Always check with your doctor before starting new supplements, especially if you’re pregnant or on medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy