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Pro-Gastrin-Releasing Peptide (ProGRP), Serum/Plasma — Immunoassay, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A blood test that measures ProGRP, a peptide sometimes used as a tumor marker in the evaluation of certain neuroendocrine tumors.

Quick summary

["An elevated ProGRP level may support further evaluation for a neuroendocrine tumor, but results must be interpreted alongside other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96461-9
Short code
ProGRP SerPl IA-mCnc
Synonyms
ProGRP SerPl IA-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of ProGRP, also called pro-gastrin-releasing peptide, in blood. ProGRP is released by some neuroendocrine cells and can be used as a tumor marker in selected cases.

Why might I need this test?

Your clinician may order ProGRP when evaluating symptoms or findings that could be related to a neuroendocrine tumor. It is usually considered alongside other laboratory tests, imaging, and the results of a physical examination.

How is the test performed?

A blood sample is collected and sent to a laboratory, where an immunoassay is used to measure the ProGRP concentration. The laboratory may use a serum or plasma sample, depending on the test method.

How do I prepare for the test?

No special preparation is commonly required, but follow your clinician's or laboratory's instructions. Tell the laboratory if you are taking medicines or supplements, because some treatments may affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ProGRP

Frequently asked questions

Is ProGRP the same as gastrin-releasing peptide?
ProGRP is a larger precursor form of gastrin-releasing peptide. The test measures the precursor in blood rather than the mature peptide.
Does an elevated ProGRP level diagnose cancer?
No. An elevated level can raise suspicion for a neuroendocrine tumor, but it does not establish a diagnosis by itself and may occur for other reasons.
What other tests may be used with ProGRP?
Depending on the clinical situation, your clinician may also order gastrin, chromogranin A, other tumor markers, and imaging studies. These results are interpreted together rather than separately.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy