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Prolactin, Serum (High Sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of prolactin, a hormone produced by the pituitary gland, in your blood. It helps diagnose conditions related to abnormal hormone levels.

Quick summary

["High-sensitivity prolactin testing supports accurate detection of low hormone levels often missed by standard tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1617-0
Short code
Prolactin 3h p L-D PO SerPl-mCnc
Synonyms
Prolactin 3h p L-D PO SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2
Ref high
18
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84146
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Ordered

Your healthcare provider may recommend this test if you have symptoms like irregular menstrual periods, infertility, unexplained breast changes, or signs of hormonal imbalances. It’s also used to monitor treatment for conditions like prolactinoma (a pituitary tumor).

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into a vein (usually in your arm) to draw blood. It usually takes about 15 minutes. Wear comfortable clothing if you need to change after the procedure.

What the Test Results Mean

Results help determine if your prolactin levels are within normal ranges or elevated, which may indicate conditions like pituitary tumors, thyroid disorders, or medications affecting hormone production.

Common Conditions Monitored

This test is critical for diagnosing and managing conditions such as hyperprolactinemia (high prolactin), infertility, galactorrhea (milk production outside pregnancy), or evaluating symptoms linked to pituitary disorders.

Reference range

Adult males: 2-18 ng/mL; Females: 2-29 ng/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

High-Sensitivity Prolactin

Frequently asked questions

What does a high prolactin level mean?
High prolactin levels may signal underlying issues like pituitary tumors, thyroid problems, or certain medications. Low levels could indicate pituitary dysfunction or other hormonal imbalances. Always discuss results with your provider.
How often should I get this test?
Frequency depends on your symptoms, medical history, and treatment plan. Your doctor will advise based on your specific needs, such as monitoring for tumors or managing hormonal conditions.
Can diet or lifestyle affect prolactin levels?
Some foods, stress, and certain medications (like antidepressants or antipsychotics) may influence prolactin levels. Avoid caffeine or smoking before testing if advised by your provider to minimize variability.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy