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Urinary Proline-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures proline relative to creatinine, helping evaluate collagen metabolism and certain inherited connective-tissue conditions.

Quick summary

["This ratio can help identify increased urinary proline, but results must be interpreted with symptoms and other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13799-2
Short code
Proline/Creat Ur
Synonyms
Proline/Creat Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

The urinary proline-to-creatinine ratio measures the amount of proline in urine relative to creatinine, a waste product that reflects urine concentration. It can provide information about collagen breakdown and metabolism.

Why might I need this test?

This test may be used when a clinician is evaluating suspected collagen or connective-tissue disorders, particularly when symptoms suggest a hereditary condition. It is interpreted together with medical history, physical findings, and other laboratory tests.

How is the test performed?

A urine sample is collected and analyzed in the laboratory. The laboratory measures proline and creatinine and calculates their ratio, often using a spot urine sample unless another collection method is specified.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. You may be asked to provide a first-morning or timed urine sample, and the container and storage requirements should be followed exactly.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Proline/Creatinine Ratio

Frequently asked questions

Is this the same as a serum proline test?
No. This test measures the relative amounts of proline and creatinine in urine rather than measuring proline concentration in blood.
What does an elevated ratio mean?
It may suggest increased proline excretion or altered collagen metabolism, including some inherited connective-tissue conditions. It does not establish a diagnosis on its own.
Can this ratio vary between urine samples?
Yes. Results can vary with urine concentration, collection timing, hydration, and other factors, so collection instructions are important.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy