Proline/Creatinine Ratio, Urine
A urine test that measures proline relative to creatinine, helping evaluate proline excretion while accounting for urine concentration.
["This test measures the amount of proline in urine relative to creatinine and may help evaluate collagen metabolism."]
Key facts at a glance
- LOINC
- 22690-2
- Short code
- Proline/Creat Ur-sRto
- Synonyms
- Proline/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Proline is an amino acid used to make proteins, including collagen. This urine test measures the amount of proline relative to creatinine, a substance used to account for differences in urine concentration.
Why might I need this test?
A clinician may order this test when there is concern about increased proline loss in the urine, a possible collagen-related disorder, or symptoms that suggest a problem affecting connective tissue, bone, or kidney function.
How is the test performed?
You provide a urine sample according to your clinician's instructions. The laboratory measures proline and creatinine in the urine and calculates their ratio. Depending on the order, the sample may be a first-morning collection, a random collection, or a timed collection.
How do I prepare for the test?
Follow the collection instructions provided by your clinician or laboratory, including whether a timed or first-morning sample is required. Fasting is generally not necessary unless your clinician specifically requests it, and medication or supplement use should be reported.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated urine proline/creatinine ratio may indicate increased urinary proline loss, which can occur with collagen disorders, abnormalities of proline metabolism, or certain kidney conditions. The result must be interpreted with symptoms, medical history, other laboratory tests, and the collection method because factors such as urine concentration and diet can affect it.
Short name
Urine proline/creatinine ratio
Frequently asked questions
What does the urine proline/creatinine ratio measure?
Does an elevated result diagnose a collagen disorder?
Do I need to fast before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy