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Proline in Cerebrospinal Fluid (CSF) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of proline, an amino acid, found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It may be checked if you have symptoms that could involve the central nervous system.

Quick summary

["Proline levels in CSF can help diagnose or monitor certain neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22645-6
Short code
Proline CSF-sCnc
Synonyms
Proline CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like headaches, seizures, or neurological issues that could be linked to abnormal fluid or protein buildup in your brain. It may also be used in research or specialized diagnostic procedures involving CSF analysis.

What Does This Test Involve?

A sample of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). This involves inserting a needle into your lower back to draw fluid from your spinal canal. The fluid is then sent to a lab for testing.

What Are Possible Results?

Results are typically reported as a concentration value (e.g., mass concentration of proline). Your healthcare provider will interpret these results in the context of your symptoms and medical history.

What Are the Normal Results?

There are no standard reference ranges provided here as proline levels can vary based on medical conditions, testing methods, and individual differences. Your results will be compared to your specific lab’s standards and clinical context.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Proline CSF

Frequently asked questions

What Does a High or Low Level Mean?
Proline levels in CSF can be elevated in certain neurological disorders, such as multiple sclerosis or certain types of brain tumors. However, abnormal results may also occur due to other conditions affecting CSF composition, like infections or trauma. Always discuss your results with your doctor.
How Often Should I Get This Test?
The frequency depends on your medical condition and treatment plan. Your healthcare provider will determine if follow-up testing is needed based on your symptoms and test results.
Can I Prepare for This Test?
No special preparation is usually required, but you may be asked to avoid certain medications or activities for a short time before the procedure. Follow your healthcare provider’s instructions carefully.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy