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Propionylcarnitine concentration (plasma or serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of propionylcarnitine, a compound formed when the body breaks down certain amino acids and fats. It helps assess how well your metabolism is processing these nutrients.

Quick summary

["This test is often used to check for metabolic disorders affecting fat and amino acid metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54331-4
Short code
Propionylcarn Amn-sCnc
Synonyms
Propionylcarn Amn-sCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained muscle weakness, fatigue, or developmental delays in children. It’s also used to monitor conditions such as organic acidemias, medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, or other inherited metabolic disorders.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the blood draw if your provider specifies. Wear a comfortable shirt for easy access to your arm.

How the Test Works

A small amount of blood is drawn from a vein in your arm. The sample is then sent to a lab to measure propionylcarnitine levels using a specialized technique, often high-performance liquid chromatography (HPLC).

What the Results Mean

High levels may indicate problems with fat metabolism or certain genetic disorders. Low levels could suggest other metabolic issues, but results alone don’t diagnose a condition. Your provider will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Propionylcarnitine

Frequently asked questions

What could cause elevated propionylcarnitine?
Elevated levels may be linked to inherited metabolic disorders, such as propionic acidemia or methylmalonic aciduria, or conditions affecting fat metabolism. Dietary factors, infections, or certain medications might also influence results.
What could cause low propionylcarnitine?
Low levels are less common but may occur in severe metabolic crises, certain genetic deficiencies, or if the body is unable to properly process nutrients. Always discuss results with your healthcare provider.
How often should I get this test?
Your provider will determine the frequency based on your health status, symptoms, and diagnosis. Regular monitoring may be needed if you have a known metabolic disorder.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy