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24-Hour Urine Propionic Acid (Organic Acids Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of propionic acid in your urine over a 24-hour period. Propionic acid is a type of organic acid that can help identify metabolic conditions, such as mitochondrial disorders or inborn errors of metabolism.

Quick summary

["This test helps diagnose metabolic disorders by tracking abnormal acid buildup in your urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44399-4
Short code
Propionylgly/Creat 24h Ur
Synonyms
Propionylgly/Creat 24h Ur
Category
glucose
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like frequent vomiting, poor growth, muscle weakness, or neurological issues. It’s also used in the evaluation of conditions linked to abnormal organic acid metabolism, such as propionic acidemia or other metabolic disorders.

Sample Collection and Preparation

You’ll collect all urine for a full 24-hour period in a clean container. Start and stop timing at the same time each day (e.g., midnight to midnight). Preserve the sample with preservative if instructed, and bring it to the lab promptly for testing.

What to Expect Before the Test

No special preparation is needed, but avoid certain medications or supplements that could interfere with results. Follow any dietary restrictions your provider gives you (e.g., avoiding high-protein foods if advised).

What the Results Mean

Elevated levels may suggest metabolic disorders, while normal levels help rule out these conditions. Results are interpreted by your healthcare provider in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Propionic Acidemia and Beyond

Short name

24h Urine Propionic Acid

Frequently asked questions

What does a high level of propionic acid in urine indicate?
High levels may indicate propionic acidemia or other metabolic disorders affecting how your body breaks down certain foods. This can lead to complications like brain damage, developmental delays, or life-threatening conditions if untreated. Your provider will work with you to manage symptoms and treatment options.
How is this test different from other organic acid tests?
Unlike single-point urine tests (e.g., for other acids like methylmalonic acid), this 24-hour test captures the total organic acid load over a full day, providing a more comprehensive picture of your metabolic health.
Can diet changes affect this test result?
Yes, certain diets (e.g., high-protein or low-carb) may influence organic acid levels. Your provider will guide you on dietary adjustments to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy