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Protein Electrophoresis (Serum/Plasma) with Bromocresol Green (BCG) Dye Binding

Published: August 9, 2026Updated: August 16, 2026

This test measures protein fractions in your blood using electrophoresis and a dye called bromocresol green. It helps identify abnormal protein patterns, which may indicate conditions like multiple myeloma, liver disease, or kidney problems.

Quick summary

["This test helps doctors check for unusual protein levels that could signal health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46747-2
Short code
PROP/MUT DBS-Imp
Synonyms
PROP/MUT DBS-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Protein electrophoresis separates blood proteins into different types (e.g., albumin, globulins) based on size and charge. The BCG dye binds to proteins, allowing for precise measurement of each fraction. This helps detect imbalances that might not be visible in a standard protein test.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if tests suggest conditions like multiple myeloma, liver disease, or kidney issues. It can also be used to monitor protein levels in chronic diseases.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is placed in a gel and subjected to an electric current, causing proteins to move through the gel. The BCG dye binds to proteins, and the results are analyzed to see how proteins separate.

What Are Common Results?

Results show the distribution of proteins, such as high or low levels of specific fractions. For example, a spike in one protein band might indicate a disease like multiple myeloma, while abnormal patterns could signal liver or kidney problems.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

BCG Protein Electrophoresis

Frequently asked questions

What Does a High or Low Protein Fraction Mean?
A high level of a specific protein fraction may signal conditions like multiple myeloma (e.g., monoclonal gammopathy), while low albumin could indicate liver disease or malnutrition. Your doctor will interpret results in the context of your symptoms and other tests.
How Often Should I Get This Test?
Your doctor will determine the frequency based on your health needs. If you have a chronic condition, this test may be part of regular monitoring. If it’s a one-time screening, results will guide future testing.
Can I Prepare for This Test?
No special preparation is needed. However, inform your doctor about any medications or conditions that might affect results, such as kidney disease or recent infections. Avoid alcohol before the test if advised.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy