Prostaglandin E2 (PGE₂) in Serum/Plasma
This test measures the amount of prostaglandin E2, a type of hormone-like substance produced by your body to help regulate inflammation, pain, and other bodily functions. It may be checked if you have symptoms related to conditions involving these processes.
["Understanding your prostaglandin E2 levels can help your healthcare provider assess inflammation or pain-related conditions."]
Key facts at a glance
- LOINC
- 70091-4
- Short code
- Prostaglandin E2 CSF-mCnc
- Synonyms
- Prostaglandin E2 CSF-mCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may order this test to evaluate conditions affecting prostaglandin production, such as inflammatory diseases, certain types of arthritis, or to monitor responses to treatments that influence prostaglandins. It may also be used in research or specialized clinical settings where prostaglandin levels are relevant.
What to Expect Before the Test
No special preparation is typically required. You may have a blood sample drawn from a vein in your arm. If you are on blood-thinning medications, let your doctor know before the test to avoid unnecessary precautions.
What the Test Results Mean
Results are not standardized across labs, so your doctor will interpret them based on your specific health needs and symptoms. High levels might suggest inflammation or certain pain conditions, while low levels could indicate reduced prostaglandin activity.
Common Conditions Monitored
This test is less commonly used in routine clinical practice but may be part of investigations for conditions like rheumatoid arthritis, menstrual cramps, or certain gastrointestinal disorders where prostaglandins play a role.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Prostaglandin E2 is involved in processes like fever regulation, pain sensation, and the body’s response to injury or infection. Elevated levels may indicate ongoing inflammation or pain, while abnormal findings could prompt further evaluation of underlying causes, such as hormonal imbalances or specific medications.
Short name
PGE₂ Level
Frequently asked questions
What does a high or low prostaglandin E2 level mean?
How often should I get this test?
Can diet or supplements affect prostaglandin E2 levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy