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Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, which helps identify abnormalities in protein distribution that may signal conditions like kidney disease, liver problems, or certain cancers.

Quick summary

["Protein electrophoresis helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27819-2
Short code
Prot C Act/Nor PPP
Synonyms
Prot C Act/Nor PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Measured?

Electrophoresis separates blood proteins based on their size and electrical charge, revealing distinct bands corresponding to albumin, globulins (including alpha, beta, and gamma globulins), and other proteins. This separation can highlight imbalances that may indicate underlying health issues.

Why Is This Test Done?

Your healthcare provider may order this test to investigate symptoms like swelling, unexplained weight loss, fatigue, or to evaluate conditions such as multiple myeloma, liver disease, or kidney disease. It can also help monitor treatment progress for certain disorders.

Common Conditions Evaluated

Abnormal protein patterns may point to conditions like multiple myeloma (overproduction of abnormal proteins), liver cirrhosis (reduced albumin), or immune system disorders (elevated gamma globulins). Kidney disease can also alter protein profiles.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in the arm. The blood is then processed to separate serum or plasma, which is sent to a lab for electrophoresis. This process does not require fasting but may be timed with other tests for consistency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis

Frequently asked questions

How long will it take to get my results?
Results are usually available within 24 to 48 hours, depending on lab processing times. Follow-up with your healthcare provider is recommended to discuss findings and next steps.
Can I eat or drink before this test?
No special diet is required for this test, but inform your provider if you have any medications or conditions that might affect blood protein levels.
What do abnormal results mean?
Abnormal results may require further testing or evaluation by a specialist. Your provider will explain the specific meaning of your results in the context of your health history and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy