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Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, including albumin, globulins, and other fractions, which help assess protein balance and potential abnormalities.

Quick summary

["This test helps identify conditions affecting protein levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27818-4
Short code
Prot C Act/Nor PPP Chro
Synonyms
Prot C Act/Nor PPP Chro
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
chromo
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to diagnose or monitor conditions like kidney disease, liver disease, infections, or certain cancers. It can also help check for protein-losing syndromes or evaluate the effectiveness of treatments targeting protein abnormalities.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from a vein. Avoid smoking or consuming alcohol for the same period if instructed.

How the Test Is Performed

A healthcare professional will collect a blood sample from a vein in your arm using a needle. The blood is then placed on a special gel in a narrow tube and subjected to an electric current to separate proteins by size and charge.

What the Results Mean

Results show the distribution of proteins across different bands (e.g., albumin, alpha, beta, gamma globulins). Abnormal patterns may indicate conditions such as multiple myeloma, autoimmune diseases, or nutritional deficiencies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

What causes abnormal protein electrophoresis results?
Abnormal results may arise from conditions like chronic kidney disease, liver disease, infections, or certain cancers (e.g., lymphoma, multiple myeloma). Genetic factors, malnutrition, or medications can also influence protein patterns.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your provider to discuss findings and next steps.
Can lifestyle changes affect protein electrophoresis results?
Yes, diet (e.g., high-protein vs. low-protein diets), hydration status, and certain medications may influence protein levels. Avoiding alcohol and smoking before testing can help ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy