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Urine Protein-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures protein relative to creatinine, helping identify and monitor kidney problems that cause protein in the urine.

Quick summary

["This ratio helps detect abnormal urine protein levels and can be used to monitor kidney conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2890-2
Short code
Prot/Creat Ur
Synonyms
Prot/Creat Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

The urine protein-to-creatinine ratio measures the amount of protein in a urine sample relative to its creatinine level. Creatinine is a waste product used to account for how concentrated the urine is.

Why might I need this test?

This test may be used to screen for kidney disease, assess a urine result that appears foamy or shows blood, and monitor conditions such as diabetes, high blood pressure, or glomerular kidney disease.

How is the test performed?

You provide a urine sample, and the laboratory measures protein and creatinine in it. The laboratory then calculates the protein-to-creatinine ratio.

How do I prepare for the test?

Follow your clinician's collection instructions and use the provided sterile container. The laboratory may request a first-morning or spot urine sample, and collection timing is especially important when results are being compared over time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Protein/Creatinine Ratio

Frequently asked questions

Does a high urine protein-to-creatinine ratio always mean I have kidney disease?
No. It can indicate a kidney problem, but temporary increases may also occur with exercise, fever, infection, or pregnancy. Your clinician will interpret the result in context and may recommend repeat testing or additional tests.
Why is the urine protein-to-creatinine ratio calculated?
Urine concentration can vary throughout the day. Comparing protein with creatinine helps account for urine concentration and makes results easier to interpret and compare over time.
Is this the same as a 24-hour urine protein test?
No. This test uses a single urine sample and estimates protein loss from the protein-to-creatinine ratio. A 24-hour urine protein test measures the total amount of protein excreted over a full day.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy