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Protein (Total) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which helps assess overall protein balance and potential issues like dehydration, kidney problems, or liver disease.

Quick summary

["Total protein levels can signal health concerns that may require further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2880-3
Short code
Prot CSF-mCnc
Synonyms
Prot CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. It can also help diagnose or monitor conditions like multiple myeloma, infections, or fluid imbalances in the body.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The blood is then sent to a lab for analysis. The test measures the combined weight of all proteins in the serum or plasma portion of your blood.

What Are Common Reasons for Abnormal Results?

Low total protein levels might indicate conditions like malnutrition, severe liver disease, kidney failure, or excessive protein loss (e.g., from kidney disease). High levels could suggest dehydration, multiple myeloma, or conditions that cause the liver to produce too much protein.

How Is the Test Performed?

The test uses a simple blood draw, and results are typically available within a few days. No special preparation is usually needed, but your doctor may advise fasting or avoiding certain medications before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What might cause my total protein test results to be different from what’s expected?
Several factors can influence your results, including recent illness, certain medications, or dietary habits. If you have ongoing symptoms like unexplained weight loss, swelling, or fatigue, discuss your results with your doctor to explore possible causes and next steps.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and any ongoing conditions. Regular monitoring may be recommended if you have chronic illnesses like kidney disease or liver disease.
Can I prepare for this test?
Most of the time, no special preparation is needed. However, if your doctor has specific instructions—for example, fasting or avoiding certain foods or supplements—follow those to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy